A: Painkillers only offer a short term hangover cure. Lifeline Hangover Defence™ helps defend against hangovers before they start. Painkillers can also have nasty side effects, such as upsetting the stomach even more when already unsettled – Lifeline™ has no known side effects, when taken as directed and is gentle on the stomach. Lifeline Hangover Defence contains no painkillers or caffeine. A proven healthy hangover pill.